Endocrine Abstracts

Objectives: Alzheimer’s disease (AD) is the most common form of dementia in the elderly. AD is characterized by the presence of amyloid plaques which are formed from deposits of β-amyloid protein (Ab). These changes increase during menopausal condition in females when the level of oestradiol (E2) is decreased. The aim of the present study was to determine the effect of neuropeptide, neurokinin B (NKB) and amyloid beta fragment Aβ (25–35) on E<sub...

Objective: The objective of this study was to investigate beneficial effects of metformin on membrane bound enzymes (monoamine oxidase, Na+K+ ATPse) and antioxidant enzymes (sueroxidase dismutase and glutathione S-transferases), lipid peroxidation, neurolipofuscin, and DNA degradation in diabetic aging female rats.Methods: Young (3 months) adult (12 months) and aged (24 months) rats will be diabetic by using alloxan monohyd...

Background: Alzheimer’s disease (AD) is the most common form of dementia in the elderly. AD is characterized by the presence of amyloid plaques which are formed from deposits of b-amyloid protein (Ab). These changes increase during menopausal condition in females when the level of estradiol is decreased.Objective: The objective of this study was to investigate neuroprotective potential of 17β estradiol (E2) treatment on the activities of acetyl...